Imaging Angiogenesis and Placental Function
Preeclampsia, a hypertensive disorder, is estimated to affect 5% to 10% of pregnancies. An initiating factor in the development of the disease is placental hypoxia. Using photoacoustic imaging, we have successfully monitored longitudinal, in vivo placental oxygenation in normal pregnancy and the reduced uterine perfusion pressure (RUPP) model of preeclampsia. Our current aim is to investigate the effect two potential therapies for preeclampsia have on placental hypoxia and maternal/fetal outcome.
Huda, K., Lawrence, D.J., Thompson, W. Lindsey, S. H., Bayer, C. L. In vivo noninvasive systemic myography of acute systemic vasoactivity in female pregnant mice. Nat Commun 14, 6286 (2023).[DOI]
Alencar, A.K.N., Swan, K.F., Mahapatra, S., Pridjian G., Lindsey S.H.. and Bayer , C. L., “G Protein-Coupled Estrogen Receptor Stimulation Attenuates Hypertension And Cardiac Dysfunction In The Reduced Uterine Perfusion Pressure Model Of Preeclampsia”. Hypertension (07 September 2023). [Poster]
Alencar, A.K.N., Swan, K.F., Mahapatra, S., Pridjian G., Bayer , C.L., “Selective activation of the G protein-coupled estrogen receptor (GPER) attenuates hypertension and cardiac dysfunction in the reduced uterine perfusion pressure model of preeclampsia.” Vasculata 2023, (19 July 2023). [Poster]
Vincely, V.D., Bavishi, S., Meadows, S. and Bayer, C.L., “Photoacoustic Tomography to Monitor Whole-Body Vascular Malformations in a SMAD4 knockout model of HHT,” NAVBO: Vasculata 2023. (18 July 2023). [POSTER].
Alencar, A.K.N., Swan K.F., Pridjian, G., Lindsey, S.H., Bayer, C.L. “Connecting G protein-coupled estrogen receptor biomolecular mechanisms with the pathophysiology of preeclampsia: a review”. Reproductive Biology and Endocrinology (2023).
Huda, K., Vincely, V.D., Bayer C.L., “Spectral photoacoustic and ultrasound imaging of vascular function.” Proc. SPIE 12363-14, Photons Plus Ultrasound: Imaging and Sensing 2023 (28 January 2023) [INVITED PAPER].
Raman, A.K., St. Clair, A., Swan, K.F., Bayer, C.L., “Evaluation of Drug Loaded Nanodroplets in a Placental Model,” BMES 2022 Annual Meeting: Photoaccoustic Imaging, (12-15 October 2022)
St. Clair, A., Raman, A.K., and Bayer, C.L., “Drug Encapsulated Perfluorocarbon Nanodroplets as a Localized Preeclampsia Theranostic,” Tulane School of Science and Engineering Undergraduate Research Poster Session, (11 October 2022) [POSTER]
D.J. Lawrence, C.L. Bayer. “Photoacoustic imaging provides an in vivo assessment of the preeclamptic placenta remodeling and function in response to therapy”. Placenta 126, 46-53 (2022).[DOI]
Bayer, CL, Modeling Longitudinal Placental Perfusion using Molecularly Targeted Contrast-Enhanced Ultrasound. 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 4th Conference on Imaging and Visualization. New York, New York. August 16, 2019.
D.J. Lawrence, K. Huda, and C.L. Bayer, “Longitudinal characterization of local perfusion of the rat placenta using contrast-enhanced ultrasound imaging,” Interface Focus, vol 9, no. 5, 2019.[DOI]
Bayer, CL, Spectral Photoacoustic Imaging of Placental Function, Current Trends in Pre-Clinical Photoacoustic Imaging of Small Animals Workshop, SPIE Medical Imaging, San Diego, CA, February 19, 2019.
D.J. Lawrence, M.E. Escott, L. Myers, S. Intapad, S.H. Lindsey, and C.L. Bayer, “Spectral photoacoustic imaging to estimate in vivo placental oxygenation during preeclampsia,” Scientific Reports, vol. 9, no. 1, 2019.[DOI]
Bayer CL, Photoacoustic Imaging of Preeclamptic Placental Function, American Institute of Ultrasound in Medicine Annual Convention, New York, New York. March 26, 2018.
Lawrence, DJ, Escott, ME, Bayer, CL, “Photoacoustic imaging of placental ischemia during preeclampsia”, Biomedical Engineering Society Annual Meeting, Phoenix, AZ, October 13, 2017.