Imaging Angiogenesis and Placental Function

Angiogen_imagePreeclampsia, a hypertensive disorder, is estimated to affect 5% to 10% of pregnancies. An initiating factor in the development of the disease is placental hypoxia. Using photoacoustic imaging, we have successfully monitored longitudinal, in vivo placental oxygenation in normal pregnancy and the reduced uterine perfusion pressure (RUPP) model of preeclampsia. Our current aim is to investigate the effect two potential therapies for preeclampsia have on placental hypoxia and maternal/fetal outcome.

References

Bayer, CL, Modeling Longitudinal Placental Perfusion using Molecularly Targeted Contrast-Enhanced Ultrasound. 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 4th Conference on Imaging and Visualization. New York, New York. August 16, 2019.

D.J. Lawrence, K. Huda, and C.L. Bayer, “Longitudinal characterization of local perfusion of the rat placenta using contrast-enhanced ultrasound imaging,” Interface Focus, vol 9, no. 5, 2019.

[DOI]

Bayer, CL, Spectral Photoacoustic Imaging of Placental Function, Current Trends in Pre-Clinical Photoacoustic Imaging of Small Animals Workshop, SPIE Medical Imaging, San Diego, CA, February 19, 2019.

D.J. Lawrence, M.E. Escott, L. Myers, S. Intapad, S.H. Lindsey, and C.L. Bayer, “Spectral photoacoustic imaging to estimate in vivo placental oxygenation during preeclampsia,” Scientific Reports, vol. 9, no. 1, 2019.

[DOI]

Bayer CL, Photoacoustic Imaging of Preeclamptic Placental Function, American Institute of Ultrasound in Medicine Annual Convention, New York, New York. March 26, 2018.

Lawrence, DJ, Escott, ME, Bayer, CL, “Photoacoustic imaging of placental ischemia during preeclampsia”, Biomedical Engineering Society Annual Meeting, Phoenix, AZ, October 13, 2017.